pharmacology summarized

1. Why is metronidazole used to treat most anaerobic protozoa and clindamycin is only for Toxoplasma?

CLINDAMYCIN, METRONIDZOLE, and CHLORAMPHENICOL treat anaerobic infections.
Tissue necrosis and abscess formation are often seen in anaerobic infections.
They seem to develop in diverticulums and in-between luminal organs.

ƒ Many of these are mixed aerobic Many of these are mixed aerobic –
anaerobic infections so it must be anaerobic anaerobic infections infections so it must be combined with aerobic agents.

An addage:
Anaerobe treatment: clindamycin above the diaphragm, metronidazole below.
This site says: For anaerobic infections above the diaphragm, penicillin G. Below the diaphragm, clindamycin, metronidazole, of chloramphenicol.
For anaerobic CNS infections: chloramphenicol or metronudazole.

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